From New Jersey:

North on New Jersey Turnpike to Palisades Parkway or Garden State Parkway to the NYS Thruway, go over the Tappan Zee Bridge.  Continue on Thruway to second exit: Exit 8 -- Cross Westchester Expressway (Route 287 East).  Take 287 East to first Exit on your right -Exit 1.  Take the fork on your right to Elmsford.  At the end of the ramp, turn right on Route 119.  Hotel is on your left.  Go to the second light, make a U turn and go onto the Hotel ramp to the parking lot.

From Connecticut:

South on Merritt Parkway, New England Thruway or Boston Post Road to Cross Westchester Expressway Route 287 West.  Stay on 287 West to Exit 1 make left turn at light--Hampton Inn is a short distance on right.

From NYC (East Side):

North on East River Drive to Triborough or Willis Avenue Bridge on Major Deegan Expressway to New York State Thruway.  North to Exit 8 for Cross Westchester Expressway Route 287 East, Exit 1, hotel directly at end of ramp.

From NYC (West Side):

North on West Side Highway to Saw Mill River Parkway to New York State Thruway North to Exit 8 for Cross Westchester Expressway Route 287 East to Exit 1, hotel directly at end of ramp.

From Long Island (Eastern):

Throggs Neck or Whitestone Bridge to New England Thruway to Cross Westchester Expressway Route 287 West to Exit 1, make a left turn at light.  Hampton Inn a short distance on right

From Long Island (Western):

Triborough Bridge to Major Deegan Expressway to New York State Thruway North to Exit 8 for Cross Westchester Expressway Route 287 East to Exit 1, hotel directly at end of ramp.